Amin Bigham-Sadegh, PhD; Iraj Karimi, PhD; Mohammad Shadkhast, PhD; Mohammad Hossein Mahdavi, DVM
Abstract
Background: Synthetic hydroxyapatite (HAP), beta-tricalcium phosphate (ß-TCP) and their composite are promising biomaterials specifically in the orthopaedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft ...
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Background: Synthetic hydroxyapatite (HAP), beta-tricalcium phosphate (ß-TCP) and their composite are promising biomaterials specifically in the orthopaedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft substitutes are gradually gaining increased acceptability. The purpose of this study was the evaluation of concurrent use of hydroxyapatite with demineralized calf foetal growth plate (DCFGP) effects on bone healing process.Methods: Mid radii bone defect was created in fifteen female New Zealand white rabbits. They were divided into 3 equal groups: In group I the defect filled with DCFGP, in group II was with hydroxyapatite and DCFGP, and in group III with hydroxyapatite alone. Radiographic and histopathologic evaluations were performed blindly and results scored and analyzed statistically.Results: There was a significant difference in bone formation and remodeling at the 56th post-operative day (p < /em>=.03). Group II was superior to group I and III. Histopathologic evaluation revealed significant difference between group II with group I and III.Conclusions: The combination of osteoconductive effect of hydroxyapatiter and osteoinduction of DCFGP will lead to superior bone healing process in comparison with any of those agents when used alone.
